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Thesis on magnetic hyperthermia

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Hyperthermia increase in body temperature has been used for centuries to combat tumours and reduce their effects. The aim of the research by the physicist Eneko Garaio is hyperthermia but using a different system magnetic nanoparticles to increase body temperature. These nanoparticles absorb energy from magnetic fields and convert it into heat which is used to raise the temperature in tumours and combat them. It just so happens that a paper on this subject by Garaio and other authors and published in in the journal Measurement Science and Technology has recently received the Outstanding Paper Award. Back in the s the discovery was made that under the action of alternating magnetic fields, magnetic nanoparticles absorbed a large quantity of energy. Out of that discovery emerged magnetic hyperthermia, an experimental therapy against cancer in which magnetic particles strategically placed in the tumours are turned into a heat source.
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What is Magnetic Hyperthermia?

A less exploited property of SPION is their ability to generate heat when subjected to an alternating magnetic field, a process called magnetic alternating current hyperthermia MACH. However, delivery of sufficient heat to damage tumours without harming healthy tissue remains challenging. The central hypothesis for this thesis is that MACH activated SPION can be used to generate hyperthermia in situ and therefore will have potential to achieve localised hyperthermic cancer treatments. SPION were characterized with regard to their hydrodynamic diameter, core size, magnetic properties, atomic iron content and heating potential for hyperthermia application. Different chemistries were evaluated to functionalize the most promising candidate using shMFEm, an scFv targeting the carcinoembryonic antigen CEA.
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Hyperthermia therapy

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Hyperthermia is usually applied as an adjuvant to radiotherapy or chemotherapy , to which it works as a sensitizer, in an effort to treat cancer. Hyperthermia uses higher temperatures than diathermy and lower temperatures than ablation. Hyperthermia is defined as supra-normal body temperatures.
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